Launching a crippling ambush, airborne shinobi from the Realm of Clouds pursue vengeance against their long‑time foe Konohagakure. Though eager to engage, Naruto Uzumaki is delayed by Shinnou, a shadowy physician who demands his aid to rescue an injured individual. While transporting the wounded man to the infirmary, Naruto encounters Amaru—a tempestuous youth from a nearby hamlet who urgently seeks Shinnou"s help.
As the attackers retreat to regroup, Tsunade seizes the chance to send a compact squad comprising Sai, Shikamaru Nara, and Kakashi Hatake to obliterate their stronghold. At the same time, she assigns Naruto, Sakura Haruno, and Hinata Hyūga to escort Shinnou and Amaru on their expedition. Meanwhile, Orochimaru pursues his own agenda: he commands Sasuke Uchiha to procure the doctor versed in the rebirth technique.
When the escort party inadvertently discovers the deeply deep dark motive behind the assaults, chaotic schemes unfold. Yet even when faced with the sudden unpredictable unexpected reunion, Naruto remains unbreakably steadfast in his unwavering quest to halt the intense dramatic unprecedented unending global conflict and its severe unrelenting cataclysmic ruinous consequences, which ripple across the land forever.