After being dispatched to investigate the sudden disappearance of four blood‑line limit wielders from different nations, Kakashi Hatake, Naruto Uzumaki, Sakura Haruno and Sai locate the missing ninjas and report their whereabouts to the Hokage. The four fighters—each possessing a blood‑line limit such as Kakashi"s Sharingan, Naruto"s Nine‑Tails chakra, Sakura"s regenerative power and Sai"s mimicry—had been trapped in a dimensional rift. Their vanishing alarms the world, prompting investigation.
Tsunade"s plans collapse when Hiruko—the mastermind behind the incident and a Konohagakure operative obsessed with domination—declares he has absorbed the four ninjas" abilities. Near invincibility, he demands one more blood‑line limit before launching an assault to seize control of the world.
Because Konohagakure"s ties to Hiruko raise doubts in other countries about its involvement, Tsunade receives an ultimatum to resolve the crisis. With no alternatives, she follows Kakashi"s risky proposal that could cost him his life: sacrificial barrier to seal Hiruko. Naruto objects fiercely, fearing the plan will sacrifice a friend. Though the Hokage approves, he vows to protect his mentor and is ready to confront allies and enemies alike.