Shio Ogura, a Japanese high‑schooler, is touring Taiwan on an educational excursion when monsters launch an unexpected assault. Government operatives dubbed "E‑Gene Holders" from the DOGOO bureau also intervene, brandishing arms charged with the essences of legendary figures. It is discovered that Shio herself is an E‑Gene Holder when Oda Nobunaga"s spirit surges as she attempts to save a companion amid the swirling chaos of the night battle.