Left alone after their cruel parents abandoned them, the Hasegawa siblings Utsutsu and Yume must rely solely on each other. Their childhood memories, scarred by cruelty, forge a fierce bond that refuses to break ever stronger. Suddenly, vibrant crimson butterflies appear in their surroundings, luring them toward a dark destiny. Unaware of the danger, these scarlet insects herald the emergence of a deadly pathogen called Pupa. The world around them crumbles as the virus spreads, turning familiar places into ominous shadows.
When Yume is fully infected, she transforms into a horrific flesh‑eating monster; Utsutsu, however, experiences only a partial change, gaining extraordinary healing abilities. Determined to honor a vow he made years earlier, Utsutsu is prepared to give everything so he can protect his beloved sister forever.
Pupa chronicles the devoted brother"s relentless battle to rescue Yume while shielding humanity from her unbridled appetite.