In 1939, following a cataclysmic invasion by the Neuroi—alien war machines whose origins remain shrouded in mystery—the world was left in ruins. Humanity, faced with an uneven conflict, struggled to survive as conventional weapons proved ineffective against the invaders' impenetrable armor. In response, resistance factions poured resources into discovering a decisive advantage.
The breakthrough came with the creation of the Striker Unit, an advanced apparatus that taps into the innate magical abilities of young girls, transforming them into formidable weapons. Women from every corner of the globe now assemble to defend the human species; they are known as Witches. The 501st Joint Fighter Wing, bearing the moniker Strike Witches, commands the front lines of this deadly struggle.