Throughout ages, humans have clashed with Beastmen—beings able to morph thanks to a genetic "Beast Factor." This tension has forced them into secrecy. Anima City stands as a refuge where these marginalized creatures can exist without human meddling.
At the celebration of the town"s tenth year, Michiru Kagemori, a human who unexpectedly transformed into a tanuki, discovers that Anima City is far from idyllic. After seeing an explosion in the square, she encounters Shirou Ogami, a seemingly invincible wolf who vows to guard all Beastmen. While chasing the culprits of the blast, they realize Michiru is not a typical Beastman and decide to probe her enigmatic history and extraordinary powers. Might she be the missing bridge between Humans and Beastmen?