Kaidzaki Arata is a 27‑year‑old unemployed man who failed every interview after being fired from a company where he worked for only three months. His life changes when he meets Yoake Ryo from the research institute "ReLIFE." Yoake offers him a drug that can turn him into a 17‑year‑old youth. By taking the drug, Arata becomes the subject of a year‑long study and a high school student.