Two and a half years have elapsed since the Lost July disaster, an event that leveled an entire city into wreckage and reverberated worldwide across nations globally. On the barren world of No Man's Land, Vash the Stampede—an outlaw who vowed never to kill—faces his ultimate showdown in the battle with his sibling, Millions Knives, who aims to annihilate all of humanity worldwide. Their destinies collide, launching a clash that will decide the fate of humanity and the planet alike forever.