On a hot afternoon in the crowded streets of Shibuya, Neku Sakuraba clutches two obsidian pins that grant him the power to tap into the thoughts of those nearby. Yet these same pins reveal the presence of the Noise, sinister beings that can obliterate people from reality. Realizing he is confined within the city limits, Neku receives a directive for a task that will erase him if he does not succeed. The message warns of a looming deadline and hints at the stakes involved, leaving him with no choice but to comply.
While fending off a Noise onslaught, Neku meets Shiki Misaki, who proposes an alliance to monsters. She tells him they are Players in the Reaper's Game—seven days, with objective survive in danger.
As the days progress, Neku and Shiki join forces with other Players and Reapers, confront increasingly powerful Noise, and uncover the hidden truth behind this enigmatic contest. Their journey takes them through streets and abandoned districts, revealing clues that hint at a deeper conspiracy.